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Friday, 30 November 2018

MS Remylienation

Stem Cells With Unusual Metabolism May Be Therapeutic Approach to Fight Inflammatory Diseases Like MS, Study Suggests

Stem Cells With Unusual Metabolism May Be Therapeutic Approach to Fight Inflammatory Diseases Like MS, Study Suggests
Human mesenchymal stem cells (hMSCs), the type of stem cells present in many tissues of adults, may be manipulated to fight inflammation and used as a cell therapy to treat inflammatory diseases like multiple sclerosis (MS), a study reports.
In the future, researchers plan to use animal models to see if the capacity of these cells to combat inflammation can be exploited to treat MS-like disease.

The research, led by a team at the Florida A&M University-Florida State University (FAMU-FSU), College of Engineering, found that hMSCs in adults can be manipulated to work in an energy-producing mode that promotes the resolution of inflammation during response to tissue injury.
hMSCs have gained extensive interest as an “off-the-shelf” potential cell therapy in the field of regenerative medicine. These type of stem cells are known for their ease of harvesting from adult donors (e.g. blood, bone, and fat tissue), and their capacity to regenerate several tissue types.
More recently, it was proposed that the tissue repair properties of hMSCs rely on their ability to modulate immune responses and help resolve inflammation at the injured site. For this to happen, hMSCs need to adapt to the local microenvironment, including changing the way they use the available nutrients to produce their energy.
Scientists found that under inflammatory conditions, these cells use sugar (glucose) alone together with oxygen to produce their energy, a type of metabolism referred to as aerobic glycolysis. Importantly, when they use this type of energy-producing mechanism, their ability to inhibit inflammation gets enhanced.
Normally, human cells prefer to use glycolysis only when oxygen is limited (e.g., during intense exercise). But recent studies have suggested that cells use this process more frequently than thought, linking it to diverse cellular functions.
Researchers exposed hMSCs grown in the lab to a natural inflammatory trigger called interferon gamma (IFN‐γ), and looked at how they responded to this stimuli. The cells switched their metabolism toward  glycolysis, which fueled their release of anti-inflammatory chemical messengers, or cytokines, and inhibited immune cell growth (specifically the proliferation of activated immune cells called T-cells).
In light of their findings, scientists propose that it one day may be possible to harness the metabolism of hMSCs “to enhance their immunomodulatory properties and therapeutic efficacy in various diseases,” the researchers wrote.
“The idea to use cells as ‘living medicine’ to cure disease has a long history,” Teng Ma, chair of the FAMU-FSU department of chemical and biomedical engineering and senior author of the study, said in an FSU  news story by Kathleen Haughney.
“We are interested in how to produce the therapeutically competent cells from a limited donor source on a large-scale and to determine whether cells from older donors are as potent as the ones from young donors. Understanding how cells use energy seems to be a key factor,” Ma added.
In the future, researchers will focus on two goals. They will investigate how to better preserve hMSCs’ metabolism and restore older cells’ metabolism to improve their immunosuppressive properties and will test if these cells are capable to treat MS-like disease in animal models.

Change overtime.

Stop complaining.

Don't wait.

Infinite move.

Wednesday, 28 November 2018

Epic thoughts. ☝️

Okay friends hope you're enjoing
reading my blog.
So from now on I'll post direct images
of my thoughts, that I usually post
on my official Instagram profile.

Now this is my latest post.

Feel free to share and comment. Also subscribe to my blog for more
such thoughts. 

Friday, 23 November 2018

Dark side of Facebook !

Facebook as social media is the most
popular on this planet Earth. It gives people
freedom to express their true believes
and stand by it. 
Now coming to the point, this addiction to Fb
gradually tends to alter the thinking of
the person. 

Few of the most common changes in the 
individual will be seen as follows:
1. Intolerance  
2. Adamant
3. Impatience 
4. Stubbornness, etc. 
To name some.

As you start to get detached from social media,
you will start noticing these improvements in you:
1. Increase in patience.
2. Better judgment.
3. You'll be more calmer.
4. Will not indulge in arguments.
5. And will start to become wiser.
To name some.

So my friends never do anything out of limit. As it
will always harm you more.