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Showing posts with label new. Show all posts

Wednesday, May 20, 2020

New AI diagnostic can predict COVID-19 without testing

New AI diagnostic can predict COVID-19 without testing
Researchers at King's College London, Massachusetts General Hospital and health science company ZOE have developed an artificial intelligence diagnostic that can predict whether someone is likely to have COVID-19 based on their symptoms. Their findings are published today in Nature Medicine.
The AI model uses data from the COVID Symptom Study app to predict COVID-19 infection, by comparing people's symptoms and the results of traditional COVID tests. Researchers say this may provide help for populations where access to testing is limited. Two clinical trials in the UK and the US are due to start shortly.
More than 3.3 million people globally have downloaded the app and are using it to report daily on their health status, whether they feel well or have any new symptoms such as persistent cough, fever, fatigue and loss of taste or smell (anosmia).
In this study, the researchers analysed data gathered from just under 2.5 million people in the UK and US who had been regularly logging their health status in the app, around a third of whom had logged symptoms associated with COVID-19. Of these, 18,374 reported having had a test for coronavirus, with 7,178 people testing positive.
The research team investigated which symptoms known to be associated with COVID-19 were most likely to be associated with a positive test. They found a wide range of symptoms compared to cold and flu, and warn against focusing only on fever and cough. Indeed, they found loss of taste and smell (anosmia) was particularly striking, with two thirds of users testing positive for coronavirus infection reporting this symptom compared with just over a fifth of the participants who tested negative. The findings suggest that anosmia is a stronger predictor of COVID-19 than fever, supporting anecdotal reports of loss of smell and taste as a common symptom of the disease.
The researchers then created a mathematical model that predicted with nearly 80% accuracy whether an individual is likely to have COVID-19 based on their age, sex and a combination of four key symptoms: loss of smell or taste, severe or persistent cough, fatigue and skipping meals. Applying this model to the entire group of over 800,000 app users experiencing symptoms predicted that just under a fifth of those who were unwell (17.42%) were likely to have COVID-19 at that time.
Researchers suggest that combining this AI prediction with widespread adoption of the app could help to identify those who are likely to be infectious as soon as the earliest symptoms start to appear, focusing tracking and testing efforts where they are most needed.
Professor Tim Spector from King's College London said: "Our results suggest that loss of taste or smell is a key early warning sign of COVID-19 infection and should be included in routine screening for the disease. We strongly urge governments and health authorities everywhere to make this information more widely known, and advise anyone experiencing sudden loss of smell or taste to assume that they are infected and follow local self-isolation guidelines."
Story Source:
Materials provided by King's College LondonNote: Content may be edited for style and length.

Journal Reference:
  1. Cristina Menni, Ana M. Valdes, Maxim B. Freidin, Carole H. Sudre, Long H. Nguyen, David A. Drew, Sajaysurya Ganesh, Thomas Varsavsky, M. Jorge Cardoso, Julia S. El-Sayed Moustafa, Alessia Visconti, Pirro Hysi, Ruth C. E. Bowyer, Massimo Mangino, Mario Falchi, Jonathan Wolf, Sebastien Ourselin, Andrew T. Chan, Claire J. Steves, Tim D. Spector. Real-time tracking of self-reported symptoms to predict potential COVID-19Nature Medicine, 2020; DOI: 10.1038/s41591-020-0916-2

Wednesday, March 11, 2020

Why is there any matter in the universe at all? New study sheds light

Subatomic particles abstract illustration (stock image). | Credit: © Peter Jurik / stock.adobe.com
Subatomic particles abstract illustration (stock image).

Scientists at the University of Sussex have measured a property of the neutron -- a fundamental particle in the universe -- more precisely than ever before. Their research is part of an investigation into why there is matter left over in the universe, that is, why all the antimatter created in the Big Bang didn't just cancel out the matter.
The team -- which included the Science and Technology Facilities Council's (STFC) Rutherford Appleton Laboratory in the UK, the Paul Scherrer Institute (PSI) in Switzerland, and a number of other institutions -- was looking into whether or not the neutron acts like an "electric compass." Neutrons are believed to be slightly asymmetrical in shape, being slightly positive at one end and slightly negative at the other -- a bit like the electrical equivalent of a bar magnet. This is the so-called "electric dipole moment" (EDM), and is what the team was looking for.
This is an important piece of the puzzle in the mystery of why matter remains in the Universe, because scientific theories about why there is matter left over also predict that neutrons have the "electric compass" property, to a greater or lesser extent. Measuring it then it helps scientists to get closer to the truth about why matter remains.
The team of physicists found that the neutron has a significantly smaller EDM than predicted by various theories about why matter remains in the universe; this makes these theories less likely to be correct, so they have to be altered, or new theories found. In fact it's been said in the literature that over the years, these EDM measurements, considered as a set, have probably disproved more theories than any other experiment in the history of physics. The results are reported today, Friday 28 February 2020, in the journal Physical Review Letters.
Professor Philip Harris, Head of the School of Mathematical and Physical Sciences and leader of the EDM group at the University of Sussex, said:
"After more than two decades of work by researchers at the University of Sussex and elsewhere, a final result has emerged from an experiment designed to address one of the most profound problems in cosmology for the last fifty years: namely, the question of why the Universe contains so much more matter than antimatter, and, indeed, why it now contains any matter at all. Why didn't the antimatter cancel out all the matter? Why is there any matter left?
"The answer relates to a structural asymmetry that should appear in fundamental particles like neutrons. This is what we've been looking for. We've found that the "electric dipole moment" is smaller than previously believed. This helps us to rule out theories about why there is matter left over -- because the theories governing the two things are linked.
"We have set a new international standard for the sensitivity of this experiment. What we're searching for in the neutron -- the asymmetry which shows that it is positive at one end and negative at the other -- is incredibly tiny. Our experiment was able to measure this in such detail that if the asymmetry could be scaled up to the size of a football, then a football scaled up by the same amount would fill the visible Universe."
The experiment is an upgraded version of apparatus originally designed by researchers at the University of Sussex and the Rutherford Appleton Laboratory (RAL), and which has held the world sensitivity record continuously from 1999 until now.
Dr Maurits van der Grinten, from the neutron EDM group at the Rutherford Appleton Laboratory (RAL), said:
"The experiment combines various state of the art technologies that all need to perform simultaneously. We're pleased that the equipment, technology and expertise developed by scientists from RAL has contributed to the work to push the limit on this important parameter"
Dr Clark Griffith, Lecturer in Physics from the School of Mathematical and Physical Sciences at the University of Sussex, said:
"This experiment brings together techniques from atomic and low energy nuclear physics, including laser-based optical magnetometry and quantum-spin manipulation. By using these multi-disciplinary tools to measure the properties of the neutron extremely precisely, we are able to probe questions relevant to high-energy particle physics and the fundamental nature of the symmetries underlying the universe. "
50,000 measurements
Any electric dipole moment that a neutron may have is tiny, and so is extremely difficult to measure. Previous measurements by other researchers have borne this out. In particular, the team had to go to great lengths to keep the local magnetic field very constant during their latest measurement. For example, every truck that drove by on the road next to the institute disturbed the magnetic field on a scale that would have been significant for the experiment, so this effect had to be compensated for during the measurement.
Also, the number of neutrons observed needed to be large enough to provide a chance to measure the electric dipole moment. The measurements ran over a period of two years. So-called ultracold neutrons, that is, neutrons with a comparatively slow speed, were measured. Every 300 seconds, a bunch of more than 10,000 neutrons was directed to the experiment and examined in detail. The researchers measured a total of 50,000 such bunches.
A new international standard is set
The researchers' latest results supported and enhanced those of their predecessors: a new international standard has been set. The size of the EDM is still too small to measure with the instruments that have been used up until now, so some theories that attempted to explain the excess of matter have become less likely. The mystery therefore remains, for the time being.
The next, more precise, measurement is already being constructed at PSI. The PSI collaboration expects to start their next series of measurements by 2021.
Search for "new physics"
The new result was determined by a group of researchers at 18 institutes and universities in Europe and the USA on the basis of data collected at PSI's ultracold neutron source. The researchers collected measurement data there over a period of two years, evaluated it very carefully in two separate teams, and were then able to obtain a more accurate result than ever before.
The research project is part of the search for "new physics" that would go beyond the so-called Standard Model of Physics, which sets out the properties of all known particles. This is also a major goal of experiments at larger facilities such as the Large Hadron Collider (LHC) at CERN.
The techniques originally developed for the first EDM measurement in the 1950s led to world-changing developments such as atomic clocks and MRI scanners, and to this day it retains its huge and ongoing impact in the field of particle physics.

Story Source:
Materials provided by University of Sussex. Original written by Anna Ford. Note: Content may be edited for style and length.

Thursday, March 5, 2020

Why is there any matter in the universe at all? New study sheds light

Subatomic particles abstract illustration (stock image). | Credit: (c) Peter Jurik / stock.adobe.com
Subatomic particles abstract illustration (stock image).

Scientists at the University of Sussex have measured a property of the neutron -- a fundamental particle in the universe -- more precisely than ever before. Their research is part of an investigation into why there is matter left over in the universe, that is, why all the antimatter created in the Big Bang didn't just cancel out the matter.
The team -- which included the Science and Technology Facilities Council's (STFC) Rutherford Appleton Laboratory in the UK, the Paul Scherrer Institute (PSI) in Switzerland, and a number of other institutions -- was looking into whether or not the neutron acts like an "electric compass." Neutrons are believed to be slightly asymmetrical in shape, being slightly positive at one end and slightly negative at the other -- a bit like the electrical equivalent of a bar magnet. This is the so-called "electric dipole moment" (EDM), and is what the team was looking for.
This is an important piece of the puzzle in the mystery of why matter remains in the Universe, because scientific theories about why there is matter left over also predict that neutrons have the "electric compass" property, to a greater or lesser extent. Measuring it then it helps scientists to get closer to the truth about why matter remains.
The team of physicists found that the neutron has a significantly smaller EDM than predicted by various theories about why matter remains in the universe; this makes these theories less likely to be correct, so they have to be altered, or new theories found. In fact it's been said in the literature that over the years, these EDM measurements, considered as a set, have probably disproved more theories than any other experiment in the history of physics. The results are reported today, Friday 28 February 2020, in the journal Physical Review Letters.
Professor Philip Harris, Head of the School of Mathematical and Physical Sciences and leader of the EDM group at the University of Sussex, said:
"After more than two decades of work by researchers at the University of Sussex and elsewhere, a final result has emerged from an experiment designed to address one of the most profound problems in cosmology for the last fifty years: namely, the question of why the Universe contains so much more matter than antimatter, and, indeed, why it now contains any matter at all. Why didn't the antimatter cancel out all the matter? Why is there any matter left?
"The answer relates to a structural asymmetry that should appear in fundamental particles like neutrons. This is what we've been looking for. We've found that the "electric dipole moment" is smaller than previously believed. This helps us to rule out theories about why there is matter left over -- because the theories governing the two things are linked.
"We have set a new international standard for the sensitivity of this experiment. What we're searching for in the neutron -- the asymmetry which shows that it is positive at one end and negative at the other -- is incredibly tiny. Our experiment was able to measure this in such detail that if the asymmetry could be scaled up to the size of a football, then a football scaled up by the same amount would fill the visible Universe."
The experiment is an upgraded version of apparatus originally designed by researchers at the University of Sussex and the Rutherford Appleton Laboratory (RAL), and which has held the world sensitivity record continuously from 1999 until now.
Dr Maurits van der Grinten, from the neutron EDM group at the Rutherford Appleton Laboratory (RAL), said:
"The experiment combines various state of the art technologies that all need to perform simultaneously. We're pleased that the equipment, technology and expertise developed by scientists from RAL has contributed to the work to push the limit on this important parameter"
Dr Clark Griffith, Lecturer in Physics from the School of Mathematical and Physical Sciences at the University of Sussex, said:
"This experiment brings together techniques from atomic and low energy nuclear physics, including laser-based optical magnetometry and quantum-spin manipulation. By using these multi-disciplinary tools to measure the properties of the neutron extremely precisely, we are able to probe questions relevant to high-energy particle physics and the fundamental nature of the symmetries underlying the universe. "
50,000 measurements
Any electric dipole moment that a neutron may have is tiny, and so is extremely difficult to measure. Previous measurements by other researchers have borne this out. In particular, the team had to go to great lengths to keep the local magnetic field very constant during their latest measurement. For example, every truck that drove by on the road next to the institute disturbed the magnetic field on a scale that would have been significant for the experiment, so this effect had to be compensated for during the measurement.
Also, the number of neutrons observed needed to be large enough to provide a chance to measure the electric dipole moment. The measurements ran over a period of two years. So-called ultracold neutrons, that is, neutrons with a comparatively slow speed, were measured. Every 300 seconds, a bunch of more than 10,000 neutrons was directed to the experiment and examined in detail. The researchers measured a total of 50,000 such bunches.
A new international standard is set
The researchers' latest results supported and enhanced those of their predecessors: a new international standard has been set. The size of the EDM is still too small to measure with the instruments that have been used up until now, so some theories that attempted to explain the excess of matter have become less likely. The mystery therefore remains, for the time being.
The next, more precise, measurement is already being constructed at PSI. The PSI collaboration expects to start their next series of measurements by 2021.
Search for "new physics"
The new result was determined by a group of researchers at 18 institutes and universities in Europe and the USA on the basis of data collected at PSI's ultracold neutron source. The researchers collected measurement data there over a period of two years, evaluated it very carefully in two separate teams, and were then able to obtain a more accurate result than ever before.
The research project is part of the search for "new physics" that would go beyond the so-called Standard Model of Physics, which sets out the properties of all known particles. This is also a major goal of experiments at larger facilities such as the Large Hadron Collider (LHC) at CERN.
The techniques originally developed for the first EDM measurement in the 1950s led to world-changing developments such as atomic clocks and MRI scanners, and to this day it retains its huge and ongoing impact in the field of particle physics.

Story Source:
Materials provided by University of Sussex. Original written by Anna Ford. Note: Content may be edited for style and length.

Friday, January 10, 2020

New study looks to biological enzymes as source of hydrogen fuel

Hydrogen symbol illustration (stock image).

Research from the University of Illinois and the University of California, Davis has chemists one step closer to recreating nature's most efficient machinery for generating hydrogen gas. This new development may help clear the path for the hydrogen fuel industry to move into a larger role in the global push toward more environmentally friendly energy sources.
The researchers report their findings in the Proceedings of the National Academy of Sciences.
Currently, hydrogen gas is produced using a very complex industrial process that limits its attractiveness to the green fuel market, the researchers said. In response, scientists are looking toward biologically synthesized hydrogen, which is far more efficient than the current human-made process, said chemistry professor and study co-author Thomas Rauchfuss.
Biological enzymes, called hydrogenases, are nature's machinery for making and burning hydrogen gas. These enzymes come in two varieties, iron-iron and nickel-iron -- named for the elements responsible for driving the chemical reactions. The new study focuses on the iron-iron variety because it does the job faster, the researchers said.
The team came into the study with a general understanding of the chemical composition of the active sites within the enzyme. They hypothesized that the sites were assembled using 10 parts: four carbon monoxide molecules, two cyanide ions, two iron ions and two groups of a sulfur-containing amino acid called cysteine.
The team discovered that it was instead more likely that the enzyme's engine was composed of two identical groups containing five chemicals: two carbon monoxide molecules, one cyanide ion, one iron ion and one cysteine group. The groups form one tightly bonded unit, and the two units combine to give the engine a total of 10 parts.
But the laboratory analysis of the lab-synthesized enzyme revealed a final surprise, Rauchfuss said. "Our recipe is incomplete. We now know that 11 bits are required to make the active site engine, not 10, and we are in the hunt for that one final bit."
Team members say they are not sure what type of applications this new understanding of the iron-iron hydrogenase enzyme will lead to, but the research could provide an assembly kit that will be instructive to other catalyst design projects.
"The take-away from this study is that it is one thing to envision using the real enzyme to produce hydrogen gas, but it is far more powerful to understand its makeup well enough to able to reproduce it for use in the lab," Rauchfuss said.
Researchers from the Oregon Health and Science University also contributed to this study.
The National Institutes of Health supported this study.

Story Source:
Materials provided by University of Illinois at Urbana-Champaign, News BureauNote: Content may be edited for style and length.

Thursday, January 9, 2020

New therapy targets gut bacteria to prevent and reverse food allergies

New therapy targets gut bacteria to prevent and reverse food allergies

A new study identifies the species of bacteria in the human infant gut that protect against food allergies, finding changes associated with the development of food allergies and an altered immune response.
Every three minutes, a food-related allergic reaction sends someone to the emergency room in the U.S. Currently, the only way to prevent a reaction is for people with food allergies to completely avoid the food to which they are allergic. Researchers are actively seeking new treatments to prevent or reverse food allergies in patients. Recent insights about the microbiome -- the complex ecosystem of microorganisms that live in the gut and other body sites -- have suggested that an altered gut microbiome may play a pivotal role in the development of food allergies. A new study, led by investigators from Brigham and Women's Hospital and Boston Children's Hospital, identifies the species of bacteria in the human infant gut that protect against food allergies, finding changes associated with the development of food allergies and an altered immune response. In preclinical studies in a mouse model of food allergy, the team found that giving an enriched oral formulation of five or six species of bacteria found in the human gut protected against food allergies and reversed established disease by reinforcing tolerance of food allergens. The team's results are published in Nature Medicine.
"This represents a sea change in our approach to therapeutics for food allergies," said co-senior author Lynn Bry, MD, PhD, director of the Massachusetts Host-Microbiome Center at the Brigham. "We've identified the microbes that are associated with protection and ones that are associated with food allergies in patients. If we administer defined consortia representing the protective microbes as a therapeutic, not only can we prevent food allergies from happening, but we can reverse existing food allergies in preclinical models. With these microbes, we are resetting the immune system."
The research team conducted studies in both humans and preclinical models to understand the key bacterial species involved in food allergies. The team repeatedly collected fecal samples every four to six months from 56 infants who developed food allergies, finding many differences when comparing their microbiota to 98 infants who did not develop food allergies. Fecal microbiota samples from infants with or without food allergies were transplanted into mice who were sensitized to eggs. Mice who received microbiota from healthy controls were more protected against egg allergy than those who received microbiota from the infants with food allergies.
Using computational approaches, researchers analyzed differences in the microbes of children with food allergies compared to those without in order to identify microbes associated with protection or food allergies in patients. The team tested to see if orally administering protective microbes to mice could prevent the development of food allergies. They developed two consortia of bacteria that were protective. Two separate consortia of five or six species of bacteria derived from the human gut that belong to species within the Clostridiales or the Bacteroidetes could suppress food allergies in the mouse model, fully protecting the mice and keeping them resistant to egg allergy. Giving other species of bacteria did not provide protection.
"It's very complicated to look at all of the microbes in the gut and make sense of what they may be doing in food allergy, but by using computational approaches, we were able to narrow in on a specific group of microbes that are associated with a protective effect," said co-first author Georg Gerber, MD, PhD, MPH, co-director of the Massachusetts Host-Microbiome Center and chief of the Division of Computational Pathology in the Department of Pathology at the Brigham. "Being able to drill down from hundreds of microbial species to just five or six or so has implications for therapeutics and, from a basic science perspective, means that we can start to figure out how these specific bacteria are conferring protection."
To understand how the bacteria species might be influencing food allergy susceptibility, the team also looked at immunological changes, both in the human infants and in mice. They found that the Clostridiales and Bacteroidetes consortia targeted two important immunological pathways and stimulated specific regulatory T cells, a class of cells that modulate the immune system, changing their profile to promote tolerant responses instead of allergic responses. These effects were found both in the pre-clinical models and also found to occur in human infants.
The new approach represents a marked contrast to oral immunotherapy, a strategy that aims to increase the threshold for triggering an allergic reaction by giving an individual small but increasing amounts of a food allergen. Unlike this approach, the bacteriotherapy changes the immune system's wiring in an allergen-independent fashion, with potential to broadly treat food allergies rather than desensitizing an individual to a specific allergen.
"When you can get down to a mechanistic understanding of what microbes, microbial products, and targets on the patient side are involved, not only are you doing great science, but it also opens up the opportunity for finding a better therapeutic and a better diagnostic approach to disease. With food allergies, this has given us a credible therapeutic that we can now take forward for patient care," said Bry.
Bry and Gerber, along with senior author Talal Chatila, MD, of Boston Children's Hospital, are founders and have equity in ConsortiaTX, a company that is developing a live human biotherapeutic product (CTX-944). (Co-senior author Rima Rachid, MD, of Boston Children's Hospital, also has equity in the company.) ConsortiaTX is preparing for a Phase 1b trial in pediatric food allergy, followed by expansion into additional allergic diseases. ConsortiaTX has obtained an exclusive global license to the intellectual property related to the microbial discoveries published in the Nature Medicine paper.

Story Source:
Materials provided by Brigham and Women's HospitalNote: Content may be edited for style and length.

Tuesday, December 24, 2019

Bioengineer Researchers Discover New Type of Cell Communication

Collective intercellular communication through ultra-fast hydrodynamic trigger waves:
Researchers studying one of the longest single cell organisms—Spirostomum ambiguum—which can grow up to lengths of 4mm (a unicellular organism observable to the naked eye) have discovered that it is also one of the fastest cells ever documented. The gargantuan protist can contract its long body by 60% within milliseconds, experiencing an acceleration force of up to 14g.

The contractile behavior protects the unicellular organism from would-be predators, as small vacuoles along the cellular membrane containing toxins are dispersed when undergoing the extreme g forces of the contraction. Remarkably, researchers have discovered that the contractions also generate long-ranged vortex flows that function as hydrodynamic signals to other Spirostomum.
This is the first time that hydrodynamic cellular signaling has been documented, and opens the door to investigating other instances where cells are communicating via long-range vorticular hydrodynamic signals.

RSF—in perspective:

RSF—in perspective: the subcellular components that allow for this blazingly fast contractile motion are microtubules. Microtubules are a central facet of current theories of quantum consciousness and cellular information processing producing memory and intelligent behavior.
As such, it is perhaps not so surprising that the intelligent behavior and communication via hydrodynamic signaling from rapid contraction by this unicellular organism involves microtubules.

Monday, December 23, 2019

New findings could lead to improved vaccinations against sexually transmitted infections

New findings could lead to improved vaccinations against sexually transmitted infections

In a study published today in the Nature Communications, researchers from King's College London have shown how skin vaccination can generate protective CD8 T-cells that are recruited to the genital tissues and could be used as a vaccination strategy for sexually transmitted infections (STIs).
One of the challenges in developing vaccines for STIs, such as HIV or herpes simplex virus, is understanding how to attract specialised immune cells, called CD8 T-cells, to take up residence in the part of the body where the virus first enters. These cells need to be in place, armed and ready to provide an immediate protective immune defence, rather than waiting for immune cells in the blood to enter the tissues which takes time.
Before this study, it was thought that vaccines ideally needed to be delivered directly to the body surface (e.g. female genital tissue) where the infection might start, so that the immune system can generate these CD8 T-cells, travel back to the vaccination site and eliminate any future virus that is encountered. However, delivering vaccines directly to the female genital tissue is neither patient friendly nor efficient.
Now the team from King's have found that their vaccination strategy marshals a platoon of immune cells, called innate lymphoid cells (ILC1) and monocytes, in the genital tissues to work together and release chemicals (chemokines) to send out a call to the CD8 T-cells generated by the vaccine to troop into the genital tissue.
This research builds on the team's earlier work to develop skin vaccination techniques using a dissolvable 'microneedle' vaccine patch that once placed against the skin dissolves and releases the vaccine without requiring a hypodermic needle injection and generates immune responses.
Lead author, Professor Linda Klavinskis from King's College London said: "This study highlights how specialised groups of 'innate' immune cells in distant tissues can be harnessed to attract protective CD8 T-cells, arming the body's frontline tissues from infection.
"We now need to confirm these results with other types of vaccines from the one used in the study to see if a common pathway is triggered by skin vaccination. If proven, this could have a significant impact in improving the effectiveness of vaccines against sexually transmitted infections."

Story Source:
Materials provided by King's College LondonNote: Content may be edited for style and length.

Friday, December 13, 2019

Quite impressed with France eh!

62 viewers from France
wow !
Thank you guys for visiting
my blog.
I'll keep you all updated with
new scientific news posts.

Saturday, December 7, 2019

NASA's Parker Solar Probe sheds new light on the sun

NASA's Parker Solar Probe sheds new light on the sun

In August 2018, NASA's Parker Solar Probe launched to space, soon becoming the closest-ever spacecraft to the Sun. With cutting-edge scientific instruments to measure the environment around the spacecraft, Parker Solar Probe has completed three of 24 planned passes through never-before-explored parts of the Sun's atmosphere, the corona. On Dec. 4, 2019, four new papers in the journal Nature describe what scientists have learned from this unprecedented exploration of our star -- and what they look forward to learning next.
These findings reveal new information about the behavior of the material and particles that speed away from the Sun, bringing scientists closer to answering fundamental questions about the physics of our star. In the quest to protect astronauts and technology in space, the information Parker has uncovered about how the Sun constantly ejects material and energy will help scientists re-write the models we use to understand and predict the space weather around our planet and understand the process by which stars are created and evolve.
"This first data from Parker reveals our star, the Sun, in new and surprising ways," said Thomas Zurbuchen, associate administrator for science at NASA Headquarters in Washington. "Observing the Sun up close rather than from a much greater distance is giving us an unprecedented view into important solar phenomena and how they affect us on Earth, and gives us new insights relevant to the understanding of active stars across galaxies. It's just the beginning of an incredibly exciting time for heliophysics with Parker at the vanguard of new discoveries."
Though it may seem placid to us here on Earth, the Sun is anything but quiet. Our star is magnetically active, unleashing powerful bursts of light, deluges of particles moving near the speed of light and billion-ton clouds of magnetized material. All this activity affects our planet, injecting damaging particles into the space where our satellites and astronauts fly, disrupting communications and navigation signals, and even -- when intense -- triggering power outages. It's been happening for the Sun's entire 5-billion-year lifetime, and will continue to shape the destinies of Earth and the other planets in our solar system into the future.
"The Sun has fascinated humanity for our entire existence," said Nour E. Raouafi, project scientist for Parker Solar Probe at the Johns Hopkins Applied Physics Laboratory in Laurel, Maryland, which built and manages the mission for NASA. "We've learned a great deal about our star in the past several decades, but we really needed a mission like Parker Solar Probe to go into the Sun's atmosphere. It's only there that we can really learn the details of these complex solar processes. And what we've learned in just these three solar orbits alone has changed a lot of what we know about the Sun."
What happens on the Sun is critical to understanding how it shapes the space around us. Most of the material that escapes the Sun is part of the solar wind, a continual outflow of solar material that bathes the entire solar system. This ionized gas, called plasma, carries with it the Sun's magnetic field, stretching it out through the solar system in a giant bubble that spans more than 10 billion miles.
The dynamic solar wind
Observed near Earth, the solar wind is a relatively uniform flow of plasma, with occasional turbulent tumbles. But by that point it's traveled over ninety million miles -- and the signatures of the Sun's exact mechanisms for heating and accelerating the solar wind are wiped out. Closer to the solar wind's source, Parker Solar Probe saw a much different picture: a complicated, active system.
"The complexity was mind-blowing when we first started looking at the data," said Stuart Bale, the University of California, Berkeley, lead for Parker Solar Probe's FIELDS instrument suite, which studies the scale and shape of electric and magnetic fields. "Now, I've gotten used to it. But when I show colleagues for the first time, they're just blown away." From Parker's vantage point 15 million miles from the Sun, Bale explained, the solar wind is much more impulsive and unstable than what we see near Earth.
Like the Sun itself, the solar wind is made up of plasma, where negatively charged electrons have separated from positively charged ions, creating a sea of free-floating particles with individual electric charge. These free-floating particles mean plasma carries electric and magnetic fields, and changes in the plasma often make marks on those fields. The FIELDS instruments surveyed the state of the solar wind by measuring and carefully analyzing how the electric and magnetic fields around the spacecraft changed over time, along with measuring waves in the nearby plasma.
These measurements showed quick reversals in the magnetic field and sudden, faster-moving jets of material -- all characteristics that make the solar wind more turbulent. These details are key to understanding how the wind disperses energy as it flows away from the Sun and throughout the solar system.
One type of event in particular drew the eye of the science teams: flips in the direction of the magnetic field, which flows out from the Sun, embedded in the solar wind. These reversals -- dubbed "switchbacks" -- last anywhere from a few seconds to several minutes as they flow over Parker Solar Probe. During a switchback, the magnetic field whips back on itself until it is pointed almost directly back at the Sun. Together, FIELDS and SWEAP, the solar wind instrument suite led by the University of Michigan and managed by the Smithsonian Astrophysical Observatory, measured clusters of switchbacks throughout Parker Solar Probe's first two flybys.
"Waves have been seen in the solar wind from the start of the space age, and we assumed that closer to the Sun the waves would get stronger, but we were not expecting to see them organize into these coherent structured velocity spikes," said Justin Kasper, principal investigator for SWEAP -- short for Solar Wind Electrons Alphas and Protons -- at the University of Michigan in Ann Arbor. "We are detecting remnants of structures from the Sun being hurled into space and violently changing the organization of the flows and magnetic field. This will dramatically change our theories for how the corona and solar wind are being heated."
The exact source of the switchbacks isn't yet understood, but Parker Solar Probe's measurements have allowed scientists to narrow down the possibilities.
Among the many particles that perpetually stream from the Sun are a constant beam of fast-moving electrons, which ride along the Sun's magnetic field lines out into the solar system. These electrons always flow strictly along the shape of the field lines moving out from the Sun, regardless of whether the north pole of the magnetic field in that particular region is pointing towards or away from the Sun. But Parker Solar Probe measured this flow of electrons going in the opposite direction, flipping back towards the Sun -- showing that the magnetic field itself must be bending back towards the Sun, rather than Parker Solar Probe merely encountering a different magnetic field line from the Sun that points in the opposite direction. This suggests that the switchbacks are kinks in the magnetic field -- localized disturbances traveling away from the Sun, rather than a change in the magnetic field as it emerges from the Sun.
Parker Solar Probe's observations of the switchbacks suggest that these events will grow even more common as the spacecraft gets closer to the Sun. The mission's next solar encounter on Jan. 29, 2020, will carry the spacecraft nearer to the Sun than ever before, and may shed new light on this process. Not only does such information help change our understanding of what causes the solar wind and space weather around us, it also helps us understand a fundamental process of how stars work and how they release energy into their environment.
The rotating solar wind
Some of Parker Solar Probe's measurements are bringing scientists closer to answers to decades-old questions. One such question is about how, exactly, the solar wind flows out from the Sun.
Near Earth, we see the solar wind flowing almost radially -- meaning it's streaming directly from the Sun, straight out in all directions. But the Sun rotates as it releases the solar wind; before it breaks free, the solar wind was spinning along with it. This is a bit like children riding on a playground park carousel -- the atmosphere rotates with the Sun much like the outer part of the carousel rotates, but the farther you go from the center, the faster you are moving in space. A child on the edge might jump off and would, at that point, move in a straight line outward, rather than continue rotating. In a similar way, there's some point between the Sun and Earth, the solar wind transitions from rotating along with the Sun to flowing directly outwards, or radially, like we see from Earth.
Exactly where the solar wind transitions from a rotational flow to a perfectly radial flow has implications for how the Sun sheds energy. Finding that point may help us better understand the lifecycle of other stars or the formation of protoplanetary disks, the dense disks of gas and dust around young stars that eventually coalesce into planets.
Now, for the first time -- rather than just seeing that straight flow that we see near Earth -- Parker Solar Probe was able to observe the solar wind while it was still rotating. It's as if Parker Solar Probe got a view of the whirling carousel directly for the first time, not just the children jumping off it. Parker Solar Probe's solar wind instrument detected rotation starting more than 20 million miles from the Sun, and as Parker approached its perihelion point, the speed of the rotation increased. The strength of the circulation was stronger than many scientists had predicted, but it also transitioned more quickly than predicted to an outward flow, which is what helps mask these effects from where we usually sit, about 93 million miles from the Sun.
"The large rotational flow of the solar wind seen during the first encounters has been a real surprise," said Kasper. "While we hoped to eventually see rotational motion closer to the Sun, the high speeds we are seeing in these first encounters is nearly ten times larger than predicted by the standard models."
Dust near the Sun
Another question approaching an answer is the elusive dust-free zone. Our solar system is awash in dust -- the cosmic crumbs of collisions that formed planets, asteroids, comets and other celestial bodies billions of years ago. Scientists have long suspected that, close to the Sun, this dust would be heated to high temperatures by powerful sunlight, turning it into a gas and creating a dust-free region around the Sun. But no one had ever observed it.
For the first time, Parker Solar Probe's imagers saw the cosmic dust begin to thin out. Because WISPR -- Parker Solar Probe's imaging instrument, led by the Naval Research Lab -- looks out the side of the spacecraft, it can see wide swaths of the corona and solar wind, including regions closer to the Sun. These images show dust starting to thin a little over 7 million miles from the Sun, and this decrease in dust continues steadily to the current limits of WISPR's measurements at a little over 4 million miles from the Sun.
"This dust-free zone was predicted decades ago, but has never been seen before," said Russ Howard, principal investigator for the WISPR suite -- short for Wide-field Imager for Solar Probe -- at the Naval Research Laboratory in Washington, D.C. "We are now seeing what's happening to the dust near the Sun."
At the rate of thinning, scientists expect to see a truly dust-free zone starting a little more than 2-3 million miles from the Sun -- meaning Parker Solar Probe could observe the dust-free zone as early as 2020, when its sixth flyby of the Sun will carry it closer to our star than ever before.
Putting space weather under a microscope
Parker Solar Probe's measurements have given us a new perspective on two types of space weather events: energetic particle storms and coronal mass ejections.
Tiny particles -- both electrons and ions -- are accelerated by solar activity, creating storms of energetic particles. Events on the Sun can send these particles rocketing out into the solar system at nearly the speed of light, meaning they reach Earth in under half an hour and can impact other worlds on similarly short time scales. These particles carry a lot of energy, so they can damage spacecraft electronics and even endanger astronauts, especially those in deep space, outside the protection of Earth's magnetic field -- and the short warning time for such particles makes them difficult to avoid.
Understanding exactly how these particles are accelerated to such high speeds is crucial. But even though they zip to Earth in as little as a few minutes, that's still enough time for the particles to lose the signatures of the processes that accelerated them in the first place. By whipping around the Sun at just a few million miles away, Parker Solar Probe can measure these particles just after they've left the Sun, shedding new light on how they are released.
Already, Parker Solar Probe's IS?IS instruments, led by Princeton University, have measured several never-before-seen energetic particle events -- events so small that all trace of them is lost before they reach Earth or any of our near-Earth satellites. These instruments have also measured a rare type of particle burst with a particularly high number of heavier elements -- suggesting that both types of events may be more common than scientists previously thought.
"It's amazing -- even at solar minimum conditions, the Sun produces many more tiny energetic particle events than we ever thought," said David McComas, principal investigator for the Integrated Science Investigation of the Sun suite, or IS?IS, at Princeton University in New Jersey. "These measurements will help us unravel the sources, acceleration, and transport of solar energetic particles and ultimately better protect satellites and astronauts in the future."
Data from the WISPR instruments also provided unprecedented detail on structures in the corona and solar wind -- including coronal mass ejections, billion-ton clouds of solar material that the Sun sends hurtling out into the solar system. CMEs can trigger a range of effects on Earth and other worlds, from sparking auroras to inducing electric currents that can damage power grids and pipelines. WISPR's unique perspective, looking alongside such events as they travel away from the Sun, has already shed new light on the range of events our star can unleash.
"Since Parker Solar Probe was matching the Sun's rotation, we could watch the outflow of material for days and see the evolution of structures," said Howard. "Observations near Earth have made us think that fine structures in the corona segue into a smooth flow, and we're finding out that's not true. This will help us do better modeling of how events travel between the Sun and Earth."
As Parker Solar Probe continues on its journey, it will make 21 more close approaches to the Sun at progressively closer distances, culminating in three orbits a mere 3.83 million miles from the solar surface.
"The Sun is the only star we can examine this closely," said Nicola Fox, director of the Heliophysics Division at NASA Headquarters. "Getting data at the source is already revolutionizing our understanding of our own star and stars across the universe. Our little spacecraft is soldiering through brutal conditions to send home startling and exciting revelations."
Data from Parker Solar Probe's first two solar encounters is available to the public online:
Parker Solar Probe is part of NASA's Living with a Star program to explore aspects of the Sun-Earth system that directly affect life and society. The Living with a Star program is managed by the agency's Goddard Space Flight Center in Greenbelt, Maryland, for NASA's Science Mission Directorate in Washington. Johns Hopkins APL designed, built and operates the spacecraft.

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Materials provided by NASA/Goddard Space Flight Center. Original written by Sarah Frazier. Note: Content may be edited for style and length.

Sunday, December 1, 2019

With Mars methane mystery unsolved, Curiosity serves scientists a new one: Oxygen

Curiosity serves scientists a new one: Oxygen

For the first time in the history of space exploration, scientists have measured the seasonal changes in the gases that fill the air directly above the surface of Gale Crater on Mars. As a result, they noticed something baffling: oxygen, the gas many Earth creatures use to breathe, behaves in a way that so far scientists cannot explain through any known chemical processes.
Over the course of three Mars years (or nearly six Earth years) an instrument in the Sample Analysis at Mars (SAM) portable chemistry lab inside the belly of NASA's Curiosity rover inhaled the air of Gale Crater and analyzed its composition. The results SAM spit out confirmed the makeup of the Martian atmosphere at the surface: 95% by volume of carbon dioxide (CO2), 2.6% molecular nitrogen (N2), 1.9% argon (Ar), 0.16% molecular oxygen (O2), and 0.06% carbon monoxide (CO). They also revealed how the molecules in the Martian air mix and circulate with the changes in air pressure throughout the year. These changes are caused when CO2 gas freezes over the poles in the winter, thereby lowering the air pressure across the planet following redistribution of air to maintain pressure equilibrium. When CO2 evaporates in the spring and summer and mixes across Mars, it raises the air pressure.
Within this environment, scientists found that nitrogen and argon follow a predictable seasonal pattern, waxing and waning in concentration in Gale Crater throughout the year relative to how much CO2 is in the air. They expected oxygen to do the same. But it didn't. Instead, the amount of the gas in the air rose throughout spring and summer by as much as 30%, and then dropped back to levels predicted by known chemistry in fall. This pattern repeated each spring, though the amount of oxygen added to the atmosphere varied, implying that something was producing it and then taking it away.
"The first time we saw that, it was just mind boggling," said Sushil Atreya, professor of climate and space sciences at the University of Michigan in Ann Arbor. Atreya is a co-author of a paper on this topic published on November 12 in the Journal of Geophysical Research: Planets.
As soon as scientists discovered the oxygen enigma, Mars experts set to work trying to explain it. They first double- and triple-checked the accuracy of the SAM instrument they used to measure the gases: the Quadrupole Mass Spectrometer. The instrument was fine. They considered the possibility that CO2 or water (H2O) molecules could have released oxygen when they broke apart in the atmosphere, leading to the short-lived rise. But it would take five times more water above Mars to produce the extra oxygen, and CO2 breaks up too slowly to generate it over such a short time. What about the oxygen decrease? Could solar radiation have broken up oxygen molecules into two atoms that blew away into space? No, scientists concluded, since it would take at least 10 years for the oxygen to disappear through this process.
"We're struggling to explain this," said Melissa Trainer, a planetary scientist at NASA's Goddard Space Flight Center in Greenbelt, Maryland who led this research. "The fact that the oxygen behavior isn't perfectly repeatable every season makes us think that it's not an issue that has to do with atmospheric dynamics. It has to be some chemical source and sink that we can't yet account for."
To scientists who study Mars, the oxygen story is curiously similar to that of methane. Methane is constantly in the air inside Gale Crater in such small quantities (0.00000004% on average) that it's barely discernable even by the most sensitive instruments on Mars. Still, it's been measured by SAM's Tunable Laser Spectrometer. The instrument revealed that while methane rises and falls seasonally, it increases in abundance by about 60% in summer months for inexplicable reasons. (In fact, methane also spikes randomly and dramatically. Scientists are trying to figure out why.)
With the new oxygen findings in hand, Trainer's team is wondering if chemistry similar to what's driving methane's natural seasonal variations may also drive oxygen's. At least occasionally, the two gases appear to fluctuate in tandem.
"We're beginning to see this tantalizing correlation between methane and oxygen for a good part of the Mars year," Atreya said. "I think there's something to it. I just don't have the answers yet. Nobody does."
Oxygen and methane can be produced both biologically (from microbes, for instance) and abiotically (from chemistry related to water and rocks). Scientists are considering all options, although they don't have any convincing evidence of biological activity on Mars. Curiosity doesn't have instruments that can definitively say whether the source of the methane or oxygen on Mars is biological or geological. Scientists expect that non-biological explanations are more likely and are working diligently to fully understand them.
Trainer's team considered Martian soil as a source of the extra springtime oxygen. After all, it's known to be rich in the element, in the form of compounds such as hydrogen peroxide and perchlorates. One experiment on the Viking landers showed decades ago that heat and humidity could release oxygen from Martian soil. But that experiment took place in conditions quite different from the Martian spring environment, and it doesn't explain the oxygen drop, among other problems. Other possible explanations also don't quite add up for now. For example, high-energy radiation of the soil could produce extra O2 in the air, but it would take a million years to accumulate enough oxygen in the soil to account for the boost measured in only one spring, the researchers report in their paper.
"We have not been able to come up with one process yet that produces the amount of oxygen we need, but we think it has to be something in the surface soil that changes seasonally because there aren't enough available oxygen atoms in the atmosphere to create the behavior we see," said Timothy McConnochie, assistant research scientist at the University of Maryland in College Park and another co-author of the paper.
The only previous spacecraft with instruments capable of measuring the composition of the Martian air near the ground were NASA's twin Viking landers, which arrived on the planet in 1976. The Viking experiments covered only a few Martian days, though, so they couldn't reveal seasonal patterns of the different gases. The new SAM measurements are the first to do so. The SAM team will continue to measure atmospheric gases so scientists can gather more detailed data throughout each season. In the meantime, Trainer and her team hope that other Mars experts will work to solve the oxygen mystery.
"This is the first time where we're seeing this interesting behavior over multiple years. We don't totally understand it," Trainer said. "For me, this is an open call to all the smart people out there who are interested in this: See what you can come up with."

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Materials provided by NASA/Goddard Space Flight CenterNote: Content may be edited for style and length.